TY - JOUR
T1 - Velocity oscillations in actin-based motility
AU - Gholami, Azam
AU - Falcke, Martin
AU - Frey, Erwin
PY - 2008/3/12
Y1 - 2008/3/12
N2 - We present a simple and generic theoretical description of actin-based motility, where polymerization of filaments maintains propulsion. The dynamics is driven by polymerization kinetics at the filaments' free ends, crosslinking of the actin network, attachment and detachment of filaments to the obstacle interface and entropic forces. We show that spontaneous oscillations in the velocity emerge due to a push-pull mechanism in a broad range of parameter values, and compare our findings with experiments.
AB - We present a simple and generic theoretical description of actin-based motility, where polymerization of filaments maintains propulsion. The dynamics is driven by polymerization kinetics at the filaments' free ends, crosslinking of the actin network, attachment and detachment of filaments to the obstacle interface and entropic forces. We show that spontaneous oscillations in the velocity emerge due to a push-pull mechanism in a broad range of parameter values, and compare our findings with experiments.
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U2 - 10.1088/1367-2630/10/3/033022
DO - 10.1088/1367-2630/10/3/033022
M3 - Article
AN - SCOPUS:46249102403
SN - 1367-2630
VL - 10
JO - New Journal of Physics
JF - New Journal of Physics
M1 - 033022
ER -