Viral evolution: Beyond drift and shift

Benjamin D. Greenbaum, Elodie Ghedin

Research output: Contribution to journalReview articlepeer-review


Technological advances have allowed aspects of viral evolution to be explored at unprecedented scales. As a consequence, new quantitative approaches are needed to investigate features of viral evolution that fall outside traditional areas of study, such as antigenic evolution. We examine three areas of viral evolution where tools from disciplines such as statistical physics, topology, and information theory have been used recently as quantitative frameworks for large-scale studies and, in some cases, suggest a novel theoretical approach to a problem. Ongoing interaction among these disciplines with biology is necessary so that experimental researchers can determine which quantitative tools are right for them and quantitative researchers can learn which aspects of viral evolution can be understood and advanced with their approaches.

Original languageEnglish (US)
Pages (from-to)109-115
Number of pages7
JournalCurrent Opinion in Microbiology
StatePublished - Aug 1 2015

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)
  • Infectious Diseases


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