Viral nanoparticles donning a paramagnetic coat: Conjugation of MRI contrast agents to the MS2 capsid

Elizabeth A. Anderson; Steven Isaacman; David S. Peabody; Edwin Y. Wang; James W. Canary; Kent Kirshenbaum

doi:10.1021/nl060378g

Viral nanoparticles donning a paramagnetic coat: Conjugation of MRI contrast agents to the MS2 capsid

Elizabeth A. Anderson, Steven Isaacman, David S. Peabody, Edwin Y. Wang, James W. Canary, Kent Kirshenbaum

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

A nanoparticle magnetic resonance imaging (MRI) contrast agent was developed by conjugation of more than 500 gadolinium chelate groups onto a viral capsid. The high density of paramagnetic centers and slow tumbling rate of modified MS2 capsids provided enhanced T ₁ relaxivities up to 7200 mM ^-1s ^-1 per particle. A bimodal imaging agent was generated by sequential conjugation of fluorescein and Gd ³⁺ chelate. These results illustrate the potential for engineering natural protein assemblies to address bionanotechnology applications.

Original language	English (US)
Pages (from-to)	1160-1164
Number of pages	5
Journal	Nano Letters
Volume	6
Issue number	6
DOIs	https://doi.org/10.1021/nl060378g
State	Published - Jun 2006

ASJC Scopus subject areas

Bioengineering
General Chemistry
General Materials Science
Condensed Matter Physics
Mechanical Engineering

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10.1021/nl060378g

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AU - Canary, James W.

AU - Kirshenbaum, Kent

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AB - A nanoparticle magnetic resonance imaging (MRI) contrast agent was developed by conjugation of more than 500 gadolinium chelate groups onto a viral capsid. The high density of paramagnetic centers and slow tumbling rate of modified MS2 capsids provided enhanced T 1 relaxivities up to 7200 mM -1s -1 per particle. A bimodal imaging agent was generated by sequential conjugation of fluorescein and Gd 3+ chelate. These results illustrate the potential for engineering natural protein assemblies to address bionanotechnology applications.

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Viral nanoparticles donning a paramagnetic coat: Conjugation of MRI contrast agents to the MS2 capsid

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