Viral nanoparticles donning a paramagnetic coat: Conjugation of MRI contrast agents to the MS2 capsid

Elizabeth A. Anderson, Steven Isaacman, David S. Peabody, Edwin Y. Wang, James W. Canary, Kent Kirshenbaum

Research output: Contribution to journalArticlepeer-review

Abstract

A nanoparticle magnetic resonance imaging (MRI) contrast agent was developed by conjugation of more than 500 gadolinium chelate groups onto a viral capsid. The high density of paramagnetic centers and slow tumbling rate of modified MS2 capsids provided enhanced T 1 relaxivities up to 7200 mM -1s -1 per particle. A bimodal imaging agent was generated by sequential conjugation of fluorescein and Gd 3+ chelate. These results illustrate the potential for engineering natural protein assemblies to address bionanotechnology applications.

Original languageEnglish (US)
Pages (from-to)1160-1164
Number of pages5
JournalNano Letters
Volume6
Issue number6
DOIs
StatePublished - Jun 2006

ASJC Scopus subject areas

  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanical Engineering

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