Visual function and brain organization in non-decussating retinal-fugal fibre syndrome

Jonathan D. Victor, Patricia Apkarian, Joy Hirsch, Mary M. Conte, Maurine Packard, Norman R. Relkin, Karl H.S. Kim, Robert M. Shapley

Research output: Contribution to journalArticle

Abstract

Functional neuroimaging, psychophysical and electrophysiological investigations were performed in a patient with non-decussating retinal-fugal fibre syndrome, an inborn achiasmatic state in which the retinal projections of each eye map entirely to the ipsilateral primary visual cortex. Functional magnetic resonance imaging (fMRI) studies showed that for monocularly presented simple visual stimuli, only the ipsilateral striate cortex was activated. Within each hemisphere's striate cortex, the representation of the two hemifields overlapped extensively. Despite this gross miswiring, visual functions that require precise geometrical information (such as vernier acuity) were normal, and there was no evidence for the confounding of visual information between the overlapping ipsilateral and contralateral representations. Contrast sensitivity and velocity judgments were abnormal, but their dependence on the orientation and velocity of the targets suggests that this deficit was due to ocular instabilities, rather than the miswiring per se. There were no asymmetries in performance observed in visual search, visual naming or illusory contour perception, fMRI analysis of the latter two tasks under monocular viewing conditions indicated extensive bilateral activation of striate and prestriate areas. Thus, the remarkably normal visual behavior achieved by this patient is a result of both the plasticity of visual pathways, and efficient transfer of information between the hemispheres.

Original languageEnglish (US)
Pages (from-to)2-22
Number of pages21
JournalCerebral Cortex
Volume10
Issue number1
DOIs
StatePublished - Jan 2000

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

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    Victor, J. D., Apkarian, P., Hirsch, J., Conte, M. M., Packard, M., Relkin, N. R., Kim, K. H. S., & Shapley, R. M. (2000). Visual function and brain organization in non-decussating retinal-fugal fibre syndrome. Cerebral Cortex, 10(1), 2-22. https://doi.org/10.1093/cercor/10.1.2