TY - JOUR
T1 - Vitamin D-dependent calcium-binding protein in the cerebellum
T2 - A marker of Purkinje cell development
AU - Thomasset, M.
AU - Rabie, A.
AU - Parkes, O.
AU - Desplan, C.
AU - Henin, D.
AU - Cuisinier-Gleizes, P.
PY - 1984
Y1 - 1984
N2 - A 28,000 molecular-weight (28 K) vitamin D-dependent calcium-binding protein (CaBP) was initially isolated from the chick intestine and then described in several avian tissues (eggshell gland and kidney) where it is possibly involved in the transepithelial transport of calcium. Based upon the number of their calcium-binding sites and their molecular weight, two classes of vitamin D-dependent CaBPs exist in mammals. In the rat the intestinal CaBP is a small protein (10,000 MW:10 K) while the predominant CaBP in the kidney and central nervous system is a larger protein (28 K) similar to the chick CaBP. We report here that the 28 K synthesized in the cerebellum is a specific marker of the development of Purkinje cells.
AB - A 28,000 molecular-weight (28 K) vitamin D-dependent calcium-binding protein (CaBP) was initially isolated from the chick intestine and then described in several avian tissues (eggshell gland and kidney) where it is possibly involved in the transepithelial transport of calcium. Based upon the number of their calcium-binding sites and their molecular weight, two classes of vitamin D-dependent CaBPs exist in mammals. In the rat the intestinal CaBP is a small protein (10,000 MW:10 K) while the predominant CaBP in the kidney and central nervous system is a larger protein (28 K) similar to the chick CaBP. We report here that the 28 K synthesized in the cerebellum is a specific marker of the development of Purkinje cells.
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U2 - 10.1159/000457220
DO - 10.1159/000457220
M3 - Article
C2 - 6518972
AN - SCOPUS:0021720647
SN - 0379-8305
VL - 7
SP - 6
EP - 10
JO - Developmental Pharmacology and Therapeutics
JF - Developmental Pharmacology and Therapeutics
IS - SUPPL. 1
ER -