Vitamin D-dependent calcium-binding protein in the cerebellum: A marker of Purkinje cell development

M. Thomasset, A. Rabie, O. Parkes, C. Desplan, D. Henin, P. Cuisinier-Gleizes

Research output: Contribution to journalArticle

Abstract

A 28,000 molecular-weight (28 K) vitamin D-dependent calcium-binding protein (CaBP) was initially isolated from the chick intestine and then described in several avian tissues (eggshell gland and kidney) where it is possibly involved in the transepithelial transport of calcium. Based upon the number of their calcium-binding sites and their molecular weight, two classes of vitamin D-dependent CaBPs exist in mammals. In the rat the intestinal CaBP is a small protein (10,000 MW:10 K) while the predominant CaBP in the kidney and central nervous system is a larger protein (28 K) similar to the chick CaBP. We report here that the 28 K synthesized in the cerebellum is a specific marker of the development of Purkinje cells.

Original languageEnglish (US)
Pages (from-to)6-10
Number of pages5
JournalDevelopmental Pharmacology and Therapeutics
Volume7
Issue numberSUPPL. 1
StatePublished - 1984

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Pharmacology (medical)

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    Thomasset, M., Rabie, A., Parkes, O., Desplan, C., Henin, D., & Cuisinier-Gleizes, P. (1984). Vitamin D-dependent calcium-binding protein in the cerebellum: A marker of Purkinje cell development. Developmental Pharmacology and Therapeutics, 7(SUPPL. 1), 6-10.