Vitro and in vivo response to collagen-coated dacron fibers

In this report, an in vitro assay showed that the Dacron-collagen composite encourages attachment and collagen production of fibroblasts to a greater degree than Dacron alone. In addition, in vivo biocompatibility assay on these materials showed that the collagen coating improved the cellular response to the implant as well as the connective tissue production around the implant. The cell culture experiments confirmed the hypothesis that collagen-coated Dacron fibers provide greater cell-binding capacity, improve cell growth, and lead to greater collagen production than uncoated fibers. These studies also confirmed that glutaraldehyde crosslinking is less biocompatibility than DMS crosslinking.