@inproceedings{903780313ac2469eac148e548f51e634,
title = "Volumetric imaging of hemodynamic effects in the human brain by three-dimensional diffuse optical tomography",
abstract = "We report on the first three dimensional tomographic localization of hemodynamic effects in the brain with diffuse optical tomography. Using a model-based iterative image reconstruction algorithms we localize spatial changes in oxy and deoxyhemoglobin.",
author = "Hielscher, {A. H.} and A. Bluestone and C. Schmitz and Barbour, {R. L.} and G. Abdoulaev",
note = "Funding Information: [1] D.A. Benaron, S.R. Hintz, A. Villringer, D. Boas, A. Kleinschmidt, J. Frahm, C. Hirth, H. Obrig, J.C. van Houten JC., E.L. Kermit, W.F. Cheong, and D.K. Stevenson, {"}Noninvasive functional imaging of human brain using light,{"} Journal of Cerebral Blood Flow & Metabolism 20(3), 469-77 (2000) [2] M. A.Franceschini, V.Toronov, M.E. Filiaci and E.Gratton, {"}On-line optical imaging of the human brain with 160-ms temporal resolution,{"} Optics Express 6( 3), 49-57 (2000). [3] S. Fantini et al, {"}Non-invasive optical monitoring of the newborn piglet brain using continuous-wave and frequency-domain spectroscopy,{"} Phys. Med. Biol. 44, 1543-1563(1999). [4] M. R. Stankovic et al, {"}Real-time optical imaging of experimental brain ischemia and hemorrhage in neonatal piglets,{"} J. Perinat. Med. 27, 279-286 (1999). [5] G. Gratton et al, {"}Dynamic brain imaging: Event-related optical signal (EROS) measures of the time course and localization of cognitive-related activity,{"} Psychonomic Bulletin and Review 5(4) 535-563 (1998). [6] M. Tamura, Y. Hoshi, and F. Okada, {"}Localized near-infrared spectroscopy and functional optical imaging of brain activity,{"} Philosophical Transactions of the Royal Society of London - Series B: Biological Sciences. 352(1354), 737-42, (1997). [7] A. Kleinschmidt et al, {"}Simultaneous recording of cerebral blood oxygenation changes during human brain activation by magnetic resonance imaging and near infrared spectroscopy,{"} J. of Cerebral Blood Flow and Metabolism 16, 817-826 (1996). [8] H. Liu, Ah. Hielscher, B. Chance, S.L. Jacques, F.K. Tittel, {"}Influence of blood vessels on the measurement of hemoglobin oxygenation as determined by time-resolved reflectance spectroscopy,{"} Med. Phys. 22(8),1209-1217 (1995). [9] Y. Hoshi and M. Tamura, {"}Detection of dynamic changes in cerebral oxygenation coupled to neuronal function during mental work in man,{"} Neuroscience Letters 150, 5-8 (1993). [10] A.H. Hielscher, A.D. Klose, K.M. Hanson, {"}Gradient-based iterative image reconstruction scheme for time-resolved optical tomography,{"} IEEE Transactions on Medical Imaging 18, 262-271, 1999. [11] A.D. Klose and A.H. Hielscher, {"}Iterative reconstruction scheme for optical tomography based on the equation of radiative transfer,{"} Medical Physics 26(8), 1698-1707, 1999. [12] Karara, H. M., Handbook of Non-topographic Photogrammetry, 2nd edition, American Society of Photogrammetry, Falls Church, VA, 1989. [13]C.H. Schmitz, M. L{\"o}cker, J. Lasker, A.H. Hielscher, R.L. Barbour, {"}Performance characteristics of a silicon-photodiode-based instrument for fast functional optical tomography,{"} in Optical Tomography and Spectroscopy of Tissue IV, SPIE-Proceedings 4250, Bellingham, WA, in press (2001). Acknowledgement: This work was supported in part by the New York City Council Speaker's Fund for Biomedical Research: Toward the Science of Patient Care, a SBIR grant (2R44-HL-61057-02) from the National Heart, Lung, and Blood Institute (NHLBI) at the National Institutes of Health (NIH), and a grant (R01-CA66184-02A) from the National Cancer Institute (NCI) at the NIH. Publisher Copyright: {\textcopyright} 2002 Optical Society of America.; Biomedical Topical Meeting, BIOMED 2002 ; Conference date: 07-04-2002 Through 10-04-2002",
year = "2002",
language = "English (US)",
series = "Optics InfoBase Conference Papers",
publisher = "Optica Publishing Group (formerly OSA)",
pages = "310--312",
booktitle = "Biomedical Topical Meeting, BIOMED 2002",
}