Volumetric quantification of in vitrosonothrombolysis with microbubbles using high-resolution optical coherence tomography

Jong S. Kim, Jonathan E. Leeman, Larry Kagemann, Francois T.H. Yu, Xucai Chen, John J. Pacella, Joel S. Schuman, Flordeliza S. Villanueva, Kang Kim

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Several in vitro and in vivo studies have established accelerated thrombolysis using ultrasound (US) induced micro-bubble (MB) cavitation. However, the mechanisms underlying MB mediated sonothrombolysis are still not completely elucidated. We performed three-dimensional (3-D) volumetric optical coherence tomography (OCT) imaging before and after the application of contrast US to thrombus. The most dramatic reduction in clot volume was observed with US + MB + recombinant tissue plasminogen activator (rt-PA). Thrombus surface erosion in this group on the side of the thrombus exposed to MB and ultrasound was evident on the OCT images. This technique may assist in clarifying the mechanisms underlying sonothrombolysis, especially regarding the importance of US transducer orientation on lytic efficacy and the effects of MB cavitation on thrombus structure.

    Original languageEnglish (US)
    Article number070502
    JournalJournal of biomedical optics
    Volume17
    Issue number7
    DOIs
    StatePublished - Jul 2012

    Keywords

    • Contrast ultrasound
    • Microbubbles
    • Optical coherence tomography
    • Sonothrombolysis

    ASJC Scopus subject areas

    • Electronic, Optical and Magnetic Materials
    • Biomaterials
    • Atomic and Molecular Physics, and Optics
    • Biomedical Engineering

    Fingerprint Dive into the research topics of 'Volumetric quantification of in vitrosonothrombolysis with microbubbles using high-resolution optical coherence tomography'. Together they form a unique fingerprint.

    Cite this