Voxel-wise group analysis of dti

Zhexing Liu, Hongtu Zhu, Bonita L. Marks, Laurence M. Katz, Casey B. Goodlett, Guido Gerig, Martin Styner

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    Diffusion tensor MRI (DTI) is now a widely used modality to investigate the fiber tissues in vivo, especially the white matter in brain. An automatic pipeline is described in this paper to conduct a localized voxel-wise multiple-subject group comparison study of DTI. The pipeline consists of 3 steps: 1) Preprocessing, including image format converting, image quality check, eddy-current and motion artifact correction, skull stripping and tensor image estimation, 2) study-specific unbiased DTI atlas computation via affine followed by fluid nonlinear registration and warping of all individual DTI images into the common atlas space to achieve voxel-wise correspondence, 3) voxel-wise statistical analysis via heterogeneous linear regression and wild bootstrap technique for correcting for multiple comparisons. This pipeline was applied to process data from a fitness and aging study and preliminary results are presented. The results show that this fully automatic pipeline is suitable for voxel-wise group DTI analysis.

    Original languageEnglish (US)
    Title of host publicationProceedings - 2009 IEEE International Symposium on Biomedical Imaging
    Subtitle of host publicationFrom Nano to Macro, ISBI 2009
    PublisherIEEE Computer Society
    Pages807-810
    Number of pages4
    ISBN (Print)9781424439324
    DOIs
    StatePublished - 2009
    Event2009 IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2009 - Boston, MA, United States
    Duration: Jun 28 2009Jul 1 2009

    Publication series

    NameProceedings - 2009 IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2009

    Other

    Other2009 IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2009
    CountryUnited States
    CityBoston, MA
    Period6/28/097/1/09

    Keywords

    • Diffusion tensor
    • Group comparison.
    • MRI
    • Voxel-wise analysis

    ASJC Scopus subject areas

    • Biomedical Engineering
    • Radiology Nuclear Medicine and imaging

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