VSV G protein induces murine cytolytic T lymphocytes

Carol S. Reiss; Steve S.L. Chen; Alice S. Huang; Richard Doherty

doi:10.1016/0882-4010(86)90050-1

VSV G protein induces murine cytolytic T lymphocytes

Carol S. Reiss, Steve S.L. Chen, Alice S. Huang, Richard Doherty

Biology and Genomics

Research output: Contribution to journal › Article › peer-review

Abstract

Mice immunized with vesicular stomatitis virus (VSV), with its glycoprotein (G) in lipid vesicles or with a truncated, soluble form of G called Gs, developed an expanded population of virus specific cytolytic T lymphocyte (CTL) precursors and also led to the production of neutralizing serum antibody. The CTL precursors could be restimulated in vitro with either the virus or its glycoprotein components. Thus the glycoprotein of VSV, either associated with lipids or in soluble form, induced both cellular and humoral immune responses that might be sufficient to result in protective immunity.

Original language	English (US)
Pages (from-to)	261-267
Number of pages	7
Journal	Microbial Pathogenesis
Volume	1
Issue number	3
DOIs	https://doi.org/10.1016/0882-4010(86)90050-1
State	Published - Jun 1986

Keywords

VSV G protein
cytolytic T lymphocytes
immunity
neutralizing antibody

ASJC Scopus subject areas

Microbiology
Infectious Diseases

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10.1016/0882-4010(86)90050-1

Cite this

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title = "VSV G protein induces murine cytolytic T lymphocytes",

abstract = "Mice immunized with vesicular stomatitis virus (VSV), with its glycoprotein (G) in lipid vesicles or with a truncated, soluble form of G called Gs, developed an expanded population of virus specific cytolytic T lymphocyte (CTL) precursors and also led to the production of neutralizing serum antibody. The CTL precursors could be restimulated in vitro with either the virus or its glycoprotein components. Thus the glycoprotein of VSV, either associated with lipids or in soluble form, induced both cellular and humoral immune responses that might be sufficient to result in protective immunity.",

keywords = "VSV G protein, cytolytic T lymphocytes, immunity, neutralizing antibody",

author = "Reiss, {Carol S.} and Chen, {Steve S.L.} and Huang, {Alice S.} and Richard Doherty",

note = "Funding Information: The authors would like to thank MS Trudy Lanman for technical support and MS lreta Ashby for assistance in manuscript preparation. C.S.R. was supported by an American Cancer Society Junior Faculty Research Award (JFRA 107) and a grant from the National Institutes of Health (Al 18083). RD. was a Harkness Fellow of the Commonwealth Fund, NY. A.S.H. and S.S.L.C. are supported by a NIH research grant (Al 20896).",

year = "1986",

month = jun,

doi = "10.1016/0882-4010(86)90050-1",

language = "English (US)",

volume = "1",

pages = "261--267",

journal = "Microbial Pathogenesis",

issn = "0882-4010",

publisher = "Academic Press Inc.",

number = "3",

}

TY - JOUR

T1 - VSV G protein induces murine cytolytic T lymphocytes

AU - Reiss, Carol S.

AU - Chen, Steve S.L.

AU - Huang, Alice S.

AU - Doherty, Richard

N1 - Funding Information: The authors would like to thank MS Trudy Lanman for technical support and MS lreta Ashby for assistance in manuscript preparation. C.S.R. was supported by an American Cancer Society Junior Faculty Research Award (JFRA 107) and a grant from the National Institutes of Health (Al 18083). RD. was a Harkness Fellow of the Commonwealth Fund, NY. A.S.H. and S.S.L.C. are supported by a NIH research grant (Al 20896).

PY - 1986/6

Y1 - 1986/6

N2 - Mice immunized with vesicular stomatitis virus (VSV), with its glycoprotein (G) in lipid vesicles or with a truncated, soluble form of G called Gs, developed an expanded population of virus specific cytolytic T lymphocyte (CTL) precursors and also led to the production of neutralizing serum antibody. The CTL precursors could be restimulated in vitro with either the virus or its glycoprotein components. Thus the glycoprotein of VSV, either associated with lipids or in soluble form, induced both cellular and humoral immune responses that might be sufficient to result in protective immunity.

AB - Mice immunized with vesicular stomatitis virus (VSV), with its glycoprotein (G) in lipid vesicles or with a truncated, soluble form of G called Gs, developed an expanded population of virus specific cytolytic T lymphocyte (CTL) precursors and also led to the production of neutralizing serum antibody. The CTL precursors could be restimulated in vitro with either the virus or its glycoprotein components. Thus the glycoprotein of VSV, either associated with lipids or in soluble form, induced both cellular and humoral immune responses that might be sufficient to result in protective immunity.

KW - VSV G protein

KW - cytolytic T lymphocytes

KW - immunity

KW - neutralizing antibody

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JO - Microbial Pathogenesis

JF - Microbial Pathogenesis

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ER -

VSV G protein induces murine cytolytic T lymphocytes

Abstract

Keywords

ASJC Scopus subject areas

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