Wave propagation mediated by GABA(B) synapse and rebound excitation in an inhibitory network: A reduced model approach

Zhixiong Chen, Bard Ermentrout, Xiao Jing Wang

Research output: Contribution to journalArticle

Abstract

A reduction method is used to analyze a spatially structured network model of inhibitory neurons. This network model displays wave propagation of postinhibitory rebound activity, which depends on GABA(B) synaptic interactions among the neurons. The reduced model allows explicit solutions for the wavefronts and their velocity as a function of various parameters, such as the synaptic coupling strength. These predictions are shown to agree well with the numerical simulations of the conductance-based biophysical model.

Original languageEnglish (US)
Pages (from-to)53-69
Number of pages17
JournalJournal of Computational Neuroscience
Volume5
Issue number1
DOIs
StatePublished - 1998

Keywords

  • GABA(B) receptor
  • Sleep spindle rhythm
  • Thalamus
  • Wavefront velocity

ASJC Scopus subject areas

  • Sensory Systems
  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

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