Abstract
This paper describes a novel application of information-asymmetric (signalling) games to molecular biology in which utility is determined by the message complexity (rate) in addition to the error in information transfer (distortion). We show using a computational model how it is possible for the agents in one such game to evolve a signalling convention (separating equilibrium) that is suboptimal in terms of information transfer, but is nonetheless stable. In the context of an RNA world merging with a nascent amino acid one, such a game's equilibrium is alluded to by the genetic code, which is nearly optimal in terms of information transfer, but is also near-universal and nearly immutable. Such a framework suggests that cellularity may have emerged to encourage coordination between RNA species and sheds light on other aspects of RNA world biochemistry yet to be fully understood.
Original language | English (US) |
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Journal | Journal of the Royal Society Interface |
Volume | 10 |
Issue number | 88 |
DOIs | |
State | Published - Nov 6 2013 |
Keywords
- Genetic code
- Information-asymmetric games
- RNA world
- Signalling
ASJC Scopus subject areas
- Biotechnology
- Biophysics
- Bioengineering
- Biomaterials
- Biochemistry
- Biomedical Engineering