What is memory? The present state of the engram

Mu ming Poo; Michele Pignatelli; Tomás J. Ryan; Susumu Tonegawa; Tobias Bonhoeffer; Kelsey C. Martin; Andrii Rudenko; Li Huei Tsai; Richard W. Tsien; Gord Fishell; Caitlin Mullins; J. Tiago Gonçalves; Matthew Shtrahman; Stephen T. Johnston; Fred H. Gage; Yang Dan; John Long; György Buzsáki; Charles Stevens

doi:10.1186/s12915-016-0261-6

What is memory? The present state of the engram

Mu ming Poo, Michele Pignatelli, Tomás J. Ryan, Susumu Tonegawa, Tobias Bonhoeffer, Kelsey C. Martin, Andrii Rudenko, Li Huei Tsai, Richard W. Tsien, Gord Fishell, Caitlin Mullins, J. Tiago Gonçalves, Matthew Shtrahman, Stephen T. Johnston, Fred H. Gage, Yang Dan, John Long, György Buzsáki, Charles Stevens

Center for Genomics and Systems Biology

Research output: Contribution to journal › Article › peer-review

Abstract

The mechanism of memory remains one of the great unsolved problems of biology. Grappling with the question more than a hundred years ago, the German zoologist Richard Semon formulated the concept of the engram, lasting connections in the brain that result from simultaneous "excitations", whose precise physical nature and consequences were out of reach of the biology of his day. Neuroscientists now have the knowledge and tools to tackle this question, however, and this Forum brings together leading contemporary views on the mechanisms of memory and what the engram means today.

Original language	English (US)
Article number	40
Journal	BMC Biology
Volume	14
Issue number	1
DOIs	https://doi.org/10.1186/s12915-016-0261-6
State	Published - May 19 2016

ASJC Scopus subject areas

Biotechnology
Structural Biology
Ecology, Evolution, Behavior and Systematics
Physiology
General Biochemistry, Genetics and Molecular Biology
General Agricultural and Biological Sciences
Plant Science
Developmental Biology
Cell Biology

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Poo, M. M., Pignatelli, M., Ryan, T. J., Tonegawa, S., Bonhoeffer, T., Martin, K. C., Rudenko, A., Tsai, L. H., Tsien, R. W., Fishell, G., Mullins, C., Gonçalves, J. T., Shtrahman, M., Johnston, S. T., Gage, F. H., Dan, Y., Long, J., Buzsáki, G., & Stevens, C. (2016). What is memory? The present state of the engram. BMC Biology, 14(1), Article 40. https://doi.org/10.1186/s12915-016-0261-6

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AU - Pignatelli, Michele

AU - Ryan, Tomás J.

AU - Tonegawa, Susumu

AU - Bonhoeffer, Tobias

AU - Martin, Kelsey C.

AU - Rudenko, Andrii

AU - Tsai, Li Huei

AU - Tsien, Richard W.

AU - Fishell, Gord

AU - Mullins, Caitlin

AU - Gonçalves, J. Tiago

AU - Shtrahman, Matthew

AU - Johnston, Stephen T.

AU - Gage, Fred H.

AU - Dan, Yang

AU - Long, John

AU - Buzsáki, György

AU - Stevens, Charles

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AB - The mechanism of memory remains one of the great unsolved problems of biology. Grappling with the question more than a hundred years ago, the German zoologist Richard Semon formulated the concept of the engram, lasting connections in the brain that result from simultaneous "excitations", whose precise physical nature and consequences were out of reach of the biology of his day. Neuroscientists now have the knowledge and tools to tackle this question, however, and this Forum brings together leading contemporary views on the mechanisms of memory and what the engram means today.

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What is memory? The present state of the engram

Abstract

ASJC Scopus subject areas

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