TY - JOUR
T1 - Whispering gallery mode bio-sensor for label-free detection of single molecules
T2 - Thermo-optic vs. reactive mechanism
AU - Arnold, S.
AU - Shopova, S. I.
AU - Holler, S.
PY - 2010/1/4
Y1 - 2010/1/4
N2 - Thermo-optic and reactive mechanisms for label-free sensing of bio-particles are compared theoretically for Whispering Gallery Mode (WGM) resonators (sphere, toroid) formed from silica and stimulated into a first order equatorial mode. Although it has been expected that a thermooptic mechanism should "greatly enhance" wavelength shift signals [A.M. Armani et al, Science 317, 783-787 (2007)] accompanying protein binding on a silica WGM cavity having high Q (108), for a combination of wavelength (680 nm), drive power (1 mW), and cavity size (43 μm radius), our calculations find no such enhancement. The possible reasons for this disparity are discussed.
AB - Thermo-optic and reactive mechanisms for label-free sensing of bio-particles are compared theoretically for Whispering Gallery Mode (WGM) resonators (sphere, toroid) formed from silica and stimulated into a first order equatorial mode. Although it has been expected that a thermooptic mechanism should "greatly enhance" wavelength shift signals [A.M. Armani et al, Science 317, 783-787 (2007)] accompanying protein binding on a silica WGM cavity having high Q (108), for a combination of wavelength (680 nm), drive power (1 mW), and cavity size (43 μm radius), our calculations find no such enhancement. The possible reasons for this disparity are discussed.
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U2 - 10.1364/OE.18.000281
DO - 10.1364/OE.18.000281
M3 - Article
C2 - 20173848
AN - SCOPUS:73549122145
SN - 1094-4087
VL - 18
SP - 281
EP - 287
JO - Optics Express
JF - Optics Express
IS - 1
ER -