Whole genome scanning identifies genotypes associated with recurrence and metastasis in prostate tumors

Pamela L. Paris, Armann Andaya, Jane Fridlyand, Ajay N. Jain, Vivian Weinberg, David Kowbel, John H. Brebner, Jeff Simko, J. E.Vivienne Watson, Stas Volik, Donna G. Albertson, Daniel Pinkel, Janneke C. Alers, Theodorus H. Van Der Kwast, Kees J. Vissers, Fritz H. Schroder, Mark F. Wildhagen, Phillip G. Febbo, Arul M. Chinnaiyan, Kenneth J. PientaPeter R. Carroll, Mark A. Rubin, Colin Collins, Herman Van Dekken

Research output: Contribution to journalArticle

Abstract

Prostate cancer is the most commonly diagnosed non-cutaneous neoplasm among American males and is the second leading cause of cancer-related death. Prostate specific antigen screening has resulted in earlier disease detection, yet ∼30% of men will die of metastatic disease. Slow disease progression, an aging population and associated morbidity and mortality underscore the need for improved disease classification and therapies. To address these issues, we analyzed a cohort of patients using array comparative genomic hybridization (aCGH). The cohort comprises 64 patients, half of whom recurred postoperatively. Analysis of the aCGH profiles revealed numerous recurrent genomic copy number aberrations. Specific loss at 8p23.2 was associated with advanced stage disease, and gain at 11q13.1 was found to be predictive of postoperative recurrence independent of stage and grade. Moreover, comparison with an independent set of metastases revealed approximately 40 candidate markers associated with metastatic potential. Copy number aberrations at these loci may define metastatic genotypes.

Original languageEnglish (US)
Pages (from-to)1303-1313
Number of pages11
JournalHuman Molecular Genetics
Volume13
Issue number13
DOIs
StatePublished - Jul 1 2004

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Genetics(clinical)

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