TY - JOUR

T1 - Whole-lesion apparent diffusion coefficient metrics as a marker of percentage Gleason 4 component within gleason 7 prostate cancer at radical prostatectomy

AU - Rosenkrantz, Andrew B.

AU - Triolo, Michael J.

AU - Melamed, Jonathan

AU - Rusinek, Henry

AU - Taneja, Samir S.

AU - Deng, Fang Ming

PY - 2015/3/1

Y1 - 2015/3/1

N2 - Purpose: To retrospectively assess the utility of wholelesion apparent diffusion coefficient (ADC) metrics in characterizing the Gleason 4 component of Gleason 7 prostate cancer (PCa) at radical prostatectomy. Materials and Methods: Seventy patients underwent phased-array coil 3T-magnetic resonance imaging (MRI) before prostatectomy. A uropathologist mapped locations and Gleason 4 percentage (G4%) of Gleason 7 tumors. Two radiologists independently reviewed ADC maps, aware of tumor locations but not G4%, and placed a volume-of-interest (VOI) on all slices including each lesion on the ADC map to obtain whole-lesion mean ADC and ADC entropy. Entropy reflects textural variation and increases with greater macroscopic heterogeneity. Performance for characterizing Gleason 7 tumors was assessed with mixed-model analysis of variance (ANOVA) and logistic regression. Results: Among 84 Gleason 7 tumors (G4% 5%-85%, median 30%; 59 Gleason 3+4, 25 Gleason 4+3), ADC entropy was significantly higher in Gleason 4+3 than Gleason 3+4 tumors (R1: 5.27±0.61 vs. 4.62±0.78, P=0.001; R2: 5.91±0.32 vs. 5.57±0.56, P=0.004); mean ADC was not significantly different between these groups (R1: 0.90±0.15∗10-3cm2/s vs. 0.98±0.21∗10-3cm2/s, P=0.075; R2: 1.06±0.19∗10-3cm2/s vs. 1.14±0.16∗10-3cm2/s, P=0.083). The area under the receiver operating characteristic (ROC) curve (AUC) for differentiating groups was significantly higher with ADC entropy than mean ADC for one observer (R1: 0.74 vs. 0.57, P=0.027; R2: 0.69 vs. 0.61, P=0.329). For R1, correlation with G4% was moderate for ADC entropy (r=0.45) and weak for mean ADC (r=-0.25). For R2, correlation with G4% was moderate for ADC entropy (r=0.41) and mean ADC (r=-0.32). For both readers, ADC entropy (P=0.028-0.003), but not mean ADC (P=0.384-0.854), was a significant independent predictor of G4%. Conclusion: Whole-lesion ADC entropy outperformed mean ADC in characterizing Gleason 7 tumors and may help refine prognosis for this heterogeneous PCa subset.

AB - Purpose: To retrospectively assess the utility of wholelesion apparent diffusion coefficient (ADC) metrics in characterizing the Gleason 4 component of Gleason 7 prostate cancer (PCa) at radical prostatectomy. Materials and Methods: Seventy patients underwent phased-array coil 3T-magnetic resonance imaging (MRI) before prostatectomy. A uropathologist mapped locations and Gleason 4 percentage (G4%) of Gleason 7 tumors. Two radiologists independently reviewed ADC maps, aware of tumor locations but not G4%, and placed a volume-of-interest (VOI) on all slices including each lesion on the ADC map to obtain whole-lesion mean ADC and ADC entropy. Entropy reflects textural variation and increases with greater macroscopic heterogeneity. Performance for characterizing Gleason 7 tumors was assessed with mixed-model analysis of variance (ANOVA) and logistic regression. Results: Among 84 Gleason 7 tumors (G4% 5%-85%, median 30%; 59 Gleason 3+4, 25 Gleason 4+3), ADC entropy was significantly higher in Gleason 4+3 than Gleason 3+4 tumors (R1: 5.27±0.61 vs. 4.62±0.78, P=0.001; R2: 5.91±0.32 vs. 5.57±0.56, P=0.004); mean ADC was not significantly different between these groups (R1: 0.90±0.15∗10-3cm2/s vs. 0.98±0.21∗10-3cm2/s, P=0.075; R2: 1.06±0.19∗10-3cm2/s vs. 1.14±0.16∗10-3cm2/s, P=0.083). The area under the receiver operating characteristic (ROC) curve (AUC) for differentiating groups was significantly higher with ADC entropy than mean ADC for one observer (R1: 0.74 vs. 0.57, P=0.027; R2: 0.69 vs. 0.61, P=0.329). For R1, correlation with G4% was moderate for ADC entropy (r=0.45) and weak for mean ADC (r=-0.25). For R2, correlation with G4% was moderate for ADC entropy (r=0.41) and mean ADC (r=-0.32). For both readers, ADC entropy (P=0.028-0.003), but not mean ADC (P=0.384-0.854), was a significant independent predictor of G4%. Conclusion: Whole-lesion ADC entropy outperformed mean ADC in characterizing Gleason 7 tumors and may help refine prognosis for this heterogeneous PCa subset.

KW - ADC

KW - Diffusion-weighted imaging

KW - Gleason score

KW - MRI

KW - Prostate cancer

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U2 - 10.1002/jmri.24598

DO - 10.1002/jmri.24598

M3 - Article

C2 - 24616064

AN - SCOPUS:84923197965

VL - 41

SP - 708

EP - 714

JO - Journal of Magnetic Resonance Imaging

JF - Journal of Magnetic Resonance Imaging

SN - 1053-1807

IS - 3

ER -