Widespread lateral gene transfer from intracellular bacteria to multicellular eukaryotes

Julie C. Dunning Hotopp, Michael E. Clark, Deodoro C S G Oliveira, Jeremy M. Foster, Peter Fischer, Mónica C. Muñoz Torres, Jonathan D. Giebel, Nikhil Kumar, Nadeeza Ishmael, Shiliang Wang, Jessica Ingram, Rahul V. Nene, Jessica Shepard, Jeffrey Tomkins, Stephen Richards, David J. Spiro, Elodie Ghedin, Barton E. Slatko, Hervé Tettelin, John H. Werren

Research output: Contribution to journalArticle

Abstract

Although common among bacteria, lateral gene transfer - the movement of genes between distantly related organisms - is thought to occur only rarely between bacteria and multicellular eukaryotes. However, the presence of endosymbionts, such as Wolbachia pipientis, within some eukaryotic germlines may facilitate bacterial gene transfers to eukaryotic host genomes. We therefore examined host genomes for evidence of gene transfer events from Wolbachia bacteria to their hosts. We found and confirmed transfers into the genomes of four insect and four nematode species that range from nearly the entire Wolbachia genome (<1 megabase) to short (>500 base pairs) insertions. Potential Wolbachia-to-host transfers were also detected computationally in three additional sequenced insect genomes. We also show that some of these inserted Wolbachia genes are transcribed within eukaryotic cells lacking endosymbionts. Therefore, heritable lateral gene transfer occurs into eukaryotic hosts from their prokaryote symbionts, potentially providing a mechanism for acquisition of new genes and functions.

Original languageEnglish (US)
Pages (from-to)1753-1756
Number of pages4
JournalScience
Volume317
Issue number5845
DOIs
StatePublished - Sep 21 2007

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    Dunning Hotopp, J. C., Clark, M. E., Oliveira, D. C. S. G., Foster, J. M., Fischer, P., Muñoz Torres, M. C., Giebel, J. D., Kumar, N., Ishmael, N., Wang, S., Ingram, J., Nene, R. V., Shepard, J., Tomkins, J., Richards, S., Spiro, D. J., Ghedin, E., Slatko, B. E., Tettelin, H., & Werren, J. H. (2007). Widespread lateral gene transfer from intracellular bacteria to multicellular eukaryotes. Science, 317(5845), 1753-1756. https://doi.org/10.1126/science.1142490