Xenopus FK 506-binding protein, a novel immunophilin expressed during early development

Rebecca Spokony; Jean Pierre Saint-Jeannet

doi:10.1016/S0925-4773(00)00315-4

Xenopus FK 506-binding protein, a novel immunophilin expressed during early development

Rebecca Spokony, Jean Pierre Saint-Jeannet

Molecular Pathobiology

Research output: Contribution to journal › Article › peer-review

Abstract

FK 506-binding proteins (FKBPs) are a family of cytosolic proteins identified by virtue of their ability to bind the immunosuppressants FK 506 and rapamycin. While their function has been extensively studied in the immune system, little is known about their role during early embryonic development. Here we describe the cloning and expression of a new Xenopus FKBP (xFKBP). xFKBP encodes a 63-kDa protein that shares high sequence homology with mouse FKBP65. It is expressed maternally and becomes restricted after the gastrula stage to dorsal mesoderm and notochord. At the tailbud stage expression persists in the notochord and begins to accumulate in epidermis, branchial arches and developing somites. In adults, xFKBP mRNA is confined to the testis. (C) 2000 Elsevier Science Ireland Ltd.

Original language	English (US)
Pages (from-to)	205-208
Number of pages	4
Journal	Mechanisms of Development
Volume	94
Issue number	1-2
DOIs	https://doi.org/10.1016/S0925-4773(00)00315-4
State	Published - Jun 1 2000

Keywords

Branchial arches
Epidermis
FK 506-binding protein
Immunophilin
Mesoderm
Notochord
Somite
Xenopus laevis

ASJC Scopus subject areas

Embryology
Developmental Biology

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10.1016/S0925-4773(00)00315-4

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title = "Xenopus FK 506-binding protein, a novel immunophilin expressed during early development",

abstract = "FK 506-binding proteins (FKBPs) are a family of cytosolic proteins identified by virtue of their ability to bind the immunosuppressants FK 506 and rapamycin. While their function has been extensively studied in the immune system, little is known about their role during early embryonic development. Here we describe the cloning and expression of a new Xenopus FKBP (xFKBP). xFKBP encodes a 63-kDa protein that shares high sequence homology with mouse FKBP65. It is expressed maternally and becomes restricted after the gastrula stage to dorsal mesoderm and notochord. At the tailbud stage expression persists in the notochord and begins to accumulate in epidermis, branchial arches and developing somites. In adults, xFKBP mRNA is confined to the testis. (C) 2000 Elsevier Science Ireland Ltd.",

keywords = "Branchial arches, Epidermis, FK 506-binding protein, Immunophilin, Mesoderm, Notochord, Somite, Xenopus laevis",

author = "Rebecca Spokony and Saint-Jeannet, {Jean Pierre}",

note = "Funding Information: The authors would like to thanks Dr Patricia Labosky for advice on library screening and Drs Yoichiro Aoki, Dan Kessler and Patricia Labosky for comments on the manuscript. This work was supported by start up funds from the Department of Animal Biology, School of Veterinary Medicine.",

year = "2000",

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doi = "10.1016/S0925-4773(00)00315-4",

language = "English (US)",

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pages = "205--208",

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AU - Spokony, Rebecca

AU - Saint-Jeannet, Jean Pierre

N1 - Funding Information: The authors would like to thanks Dr Patricia Labosky for advice on library screening and Drs Yoichiro Aoki, Dan Kessler and Patricia Labosky for comments on the manuscript. This work was supported by start up funds from the Department of Animal Biology, School of Veterinary Medicine.

PY - 2000/6/1

Y1 - 2000/6/1

N2 - FK 506-binding proteins (FKBPs) are a family of cytosolic proteins identified by virtue of their ability to bind the immunosuppressants FK 506 and rapamycin. While their function has been extensively studied in the immune system, little is known about their role during early embryonic development. Here we describe the cloning and expression of a new Xenopus FKBP (xFKBP). xFKBP encodes a 63-kDa protein that shares high sequence homology with mouse FKBP65. It is expressed maternally and becomes restricted after the gastrula stage to dorsal mesoderm and notochord. At the tailbud stage expression persists in the notochord and begins to accumulate in epidermis, branchial arches and developing somites. In adults, xFKBP mRNA is confined to the testis. (C) 2000 Elsevier Science Ireland Ltd.

AB - FK 506-binding proteins (FKBPs) are a family of cytosolic proteins identified by virtue of their ability to bind the immunosuppressants FK 506 and rapamycin. While their function has been extensively studied in the immune system, little is known about their role during early embryonic development. Here we describe the cloning and expression of a new Xenopus FKBP (xFKBP). xFKBP encodes a 63-kDa protein that shares high sequence homology with mouse FKBP65. It is expressed maternally and becomes restricted after the gastrula stage to dorsal mesoderm and notochord. At the tailbud stage expression persists in the notochord and begins to accumulate in epidermis, branchial arches and developing somites. In adults, xFKBP mRNA is confined to the testis. (C) 2000 Elsevier Science Ireland Ltd.

KW - Branchial arches

KW - Epidermis

KW - FK 506-binding protein

KW - Immunophilin

KW - Mesoderm

KW - Notochord

KW - Somite

KW - Xenopus laevis

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U2 - 10.1016/S0925-4773(00)00315-4

DO - 10.1016/S0925-4773(00)00315-4

M3 - Article

C2 - 10842073

AN - SCOPUS:0034212392

SN - 0925-4773

VL - 94

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EP - 208

JO - Mechanisms of Development

JF - Mechanisms of Development

IS - 1-2

ER -

Xenopus FK 506-binding protein, a novel immunophilin expressed during early development

Abstract

Keywords

ASJC Scopus subject areas

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