Xenopus FK 506-binding protein, a novel immunophilin expressed during early development

Rebecca Spokony, Jean Pierre Saint-Jeannet

Research output: Contribution to journalArticle

Abstract

FK 506-binding proteins (FKBPs) are a family of cytosolic proteins identified by virtue of their ability to bind the immunosuppressants FK 506 and rapamycin. While their function has been extensively studied in the immune system, little is known about their role during early embryonic development. Here we describe the cloning and expression of a new Xenopus FKBP (xFKBP). xFKBP encodes a 63-kDa protein that shares high sequence homology with mouse FKBP65. It is expressed maternally and becomes restricted after the gastrula stage to dorsal mesoderm and notochord. At the tailbud stage expression persists in the notochord and begins to accumulate in epidermis, branchial arches and developing somites. In adults, xFKBP mRNA is confined to the testis. (C) 2000 Elsevier Science Ireland Ltd.

Original languageEnglish (US)
Pages (from-to)205-208
Number of pages4
JournalMechanisms of Development
Volume94
Issue number1-2
DOIs
StatePublished - Jun 1 2000

Keywords

  • Branchial arches
  • Epidermis
  • FK 506-binding protein
  • Immunophilin
  • Mesoderm
  • Notochord
  • Somite
  • Xenopus laevis

ASJC Scopus subject areas

  • Embryology
  • Developmental Biology

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