Young and old Pavlovian fear memories can be modified with extinction training during

Elisa C K Steinfurth; Jonathan W. Kanen; Candace M. Raio; Roger L. Clem; Richard L. Huganir; Elizabeth A. Phelps

doi:10.1101/lm.033589.113

Young and old Pavlovian fear memories can be modified with extinction training during

Elisa C K Steinfurth, Jonathan W. Kanen, Candace M. Raio, Roger L. Clem, Richard L. Huganir, Elizabeth A. Phelps

Psychology

Research output: Contribution to journal › Article › peer-review

Abstract

Extinction training during reconsolidation has been shown to persistently diminish conditioned fear responses across species. We investigated in humans if older fear memories can benefit similarly. Using a Pavlovian fear conditioning paradigm we compared standard extinction and extinction after memory reactivation 1 d or 7 d following acquisition. Participants who underwent extinction during reconsolidation showed no evidence of fear recovery, whereas fear responses returned in participants who underwent standard extinction. We observed this effect in young and old fear memories. Extending the beneficial use of reconsolidation to older fear memories in humans is promising for therapeutic applications.

Original language	English (US)
Pages (from-to)	338-341
Number of pages	4
Journal	Learning and Memory
Volume	21
Issue number	7
DOIs	https://doi.org/10.1101/lm.033589.113
State	Published - Jul 2014

ASJC Scopus subject areas

Neuropsychology and Physiological Psychology
Cognitive Neuroscience
Cellular and Molecular Neuroscience

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10.1101/lm.033589.113

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abstract = "Extinction training during reconsolidation has been shown to persistently diminish conditioned fear responses across species. We investigated in humans if older fear memories can benefit similarly. Using a Pavlovian fear conditioning paradigm we compared standard extinction and extinction after memory reactivation 1 d or 7 d following acquisition. Participants who underwent extinction during reconsolidation showed no evidence of fear recovery, whereas fear responses returned in participants who underwent standard extinction. We observed this effect in young and old fear memories. Extending the beneficial use of reconsolidation to older fear memories in humans is promising for therapeutic applications.",

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Young and old Pavlovian fear memories can be modified with extinction training during

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