@article{186e5734bb484113b9da829bb9dc2f26,
title = "Z-DNA conformation of N-2-acetylaminofluorene modified poly(dG-dC)·poly(dG-dC) determined by reactivity with anti cytidine antibodies and minimized potential energy calculations",
abstract = "The conformation of poly(dG-dC)·poly(dG-dC), poly(dG)·poly(dC), and calf thymus DNA modified with N-acetoxy-N-2-acetylaminofluorene (N-acetoxy-AAF) was examined by extent of reaction with anti cytidine antibodies. In contrast to modified poly(dG)·poly(dC) and DNA, modified poly(dG-dC)·poly(dG-dC) failed to react with the antibodies indicating that the base pairing in this polymer is intact. This is consistent with induction of the Z-DNA conformation in AAF modified poly(dG-dC)·poly(dG-dC). Using minimized potential energy calculations on the dCpdG-AAF dimer as a model for the modified polymer, it is shown that the proposed Z-DNA conformation is energetically stable. A model is proposed for an AAF modified tetramer, dGpdCpdGpdC, in which the AAF is external to the Z-DNA duplex.",
author = "Santella, {Regina M.} and Dezider Grunberger and Suse Broyde and Hingerty, {Brian E.}",
note = "Funding Information: This investigation was supported by Grants CA 21111 and 13696 awarded by the National Cancer Institute, DHHS (RMS & DG); by National Institutes of Health Grant 1 R01 CA 28038-01A1, BRSG Grant RR07062, DOE Contract 0DE-ACO2-81 ER60015 (SB), American Cancer Society Institutional Grant to New York University, IN-14V, and by a grant of computer time on the CDC 6600 at the Courant Institute of New York University, supported by the U.S. Dept. of Energy under Contract #DE-AC02-76ER03077 (SB); and by the Office of Health and Environmental Research, U.S. Dept. of Energy, under Contract #W-7405-eng-26 with the Union Carbide Corp. (BH).",
year = "1981",
month = oct,
day = "24",
doi = "10.1093/nar/9.20.5459",
language = "English (US)",
volume = "9",
pages = "5459--5467",
journal = "Nucleic acids research",
issn = "0305-1048",
publisher = "Oxford University Press",
number = "20",
}