Zirconium-BINOLate-catalyzed, enantioselective aldol-Tishchenko reactions of aromatic ketone aldols

Christoph Schneider, Markus Hansch, Pankajakshan Sreekumar

Research output: Contribution to journalArticle

Abstract

3,3′-Substituted BINOL's have been identified as suitable chiral ligands for the zirconium-catalyzed aldol-Tishchenko reaction of aromatic ketone aldols with aliphatic aldehydes. 1,3-anti-Diol monoesters were obtained in excellent yields, complete anti-diastereocontrol, and enantioselectivities of up to 60% ee.

Original languageEnglish (US)
Pages (from-to)2738-2742
Number of pages5
JournalTetrahedron Asymmetry
Volume17
Issue number19
DOIs
StatePublished - Oct 27 2006

ASJC Scopus subject areas

  • Catalysis
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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