TY - JOUR
T1 - Zirconium-BINOLate-catalyzed, enantioselective aldol-Tishchenko reactions of aromatic ketone aldols
AU - Schneider, Christoph
AU - Hansch, Markus
AU - Sreekumar, Pankajakshan
N1 - Funding Information:
This work was supported by the Deutsche Forschungsgemeinschaft (Schn 441/4-1) and the Fonds der Chemischen Industrie. We thank Wacker AG for a generous donation of TBDMSCl.
PY - 2006/10/27
Y1 - 2006/10/27
N2 - 3,3′-Substituted BINOL's have been identified as suitable chiral ligands for the zirconium-catalyzed aldol-Tishchenko reaction of aromatic ketone aldols with aliphatic aldehydes. 1,3-anti-Diol monoesters were obtained in excellent yields, complete anti-diastereocontrol, and enantioselectivities of up to 60% ee.
AB - 3,3′-Substituted BINOL's have been identified as suitable chiral ligands for the zirconium-catalyzed aldol-Tishchenko reaction of aromatic ketone aldols with aliphatic aldehydes. 1,3-anti-Diol monoesters were obtained in excellent yields, complete anti-diastereocontrol, and enantioselectivities of up to 60% ee.
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U2 - 10.1016/j.tetasy.2006.10.019
DO - 10.1016/j.tetasy.2006.10.019
M3 - Article
AN - SCOPUS:33751163266
SN - 0957-4166
VL - 17
SP - 2738
EP - 2742
JO - Tetrahedron Asymmetry
JF - Tetrahedron Asymmetry
IS - 19
ER -