Surprising catalyst-based regiocontrol: Copper or zinc salts can be employed for the insertion of various carbonyl compounds into silacyclopropanes to afford, respectively, the 1,2- and 1,3-regioisomers of the product with > 99:1 regioselectivity (see scheme). Catalysis by ZnBr2 allows access to previously unobserved products. The effects of additives such as H2O, menthol, and di-tert-butylpyridine on the regioselectivity of this insertion process are described.
|Original language||English (US)|
|Number of pages||5|
|Journal||Angewandte Chemie - International Edition|
|State||Published - Dec 4 2000|
- Synthetic methods
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